Cortisone is a corticosteroid released by the adrenal gland in response to stress and is a potent anti-inflammatory agent. Artificial preparations containing cortisone are injected directly into the affected joint to relieve pain and reduce inflammation. The effects may last for several weeks, and cortisone injections are recommended for injuries that cause pain & inflammation and those that don't require surgery. Cortisone injections offer significant relief in pain & inflammation however may associated with certain adverse effects. The most common side effect is a "cortisone flare", a condition where cortisone causes pain for a brief period that lasts for a day or two. Cortisone flare can be minimized by applying ice to the injected area.